Uncertain Influences: Genetics, Pathology, and Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that primarily affects individuals above the age of 65 and is often associated with memory loss, one of its chief symptoms. Although it was first discovered by Alois Alzheimer in 1906, AD has only recently garnered attention proportionate to the impact it is expected to have as the world’s population ages at increasing rates. Despite the certainty of this its importance, there is much the medical and scientific communities do not know about the etiology of this disease. This paper will discuss a few of the reasons for this lack of knowledge by specifically describing the definite but unclear influence of genetics and pathology on the clinical symptoms of AD

Quantification of surface runoff in Patiala-Ki-Rao watersheds using modified NRCS model: a case study

Quantification of the surface runoff in a watershed is of vital importance for solution of many water resource problems. It can be quantified by employing large number of estimation approaches. Of these, SCS-CN approach is quite simple effective and requires less number of parameters. Thus, the objective of the study was to employ soil conservation service-curve number (SCS-CN) approach and their modifications to estimate surface runoff for Patiala-Ki-Rao watershed, district SAS, Nagar, Punjab and to choose the best model of the 8-different employed models. Soil moisture retention parameter was characterised and optimised by using the descriptive statistics and later used in the models. The mean and median valueof soil moisture retention parameter was 47.2 mm and 35.9 mm for June to September months and 35.4 to 30.8 mm for October to March months. The models were evaluated on the basis of Root Mean Square Error (RMSE), Nash- Scutcliffe Efficiency (NSE), Coefficient of Determination (R2) and Per cent Bias (PB). Of the evaluated and tested models, NRCS model (M5) performed best with the highest score of 32 and 31 by employing mean andmedian values of soil moisture retention parameter in Patiala-Ki-Rao watersheds over the other models. Further, the results of the study suggested in evaluating the performance of NRCS model (M5) in other treated micro-watersheds at Patiala-Ki-Rao, Punjab, over the control

Effectiveness of English Multimedia Assisted Instructional Package in Enhancing Achievement in English among Standard IX Students in Relation to their Interest in Learning

According to today’s pedagogical practices, the key to engagement of students and the effectiveness of the procedure is through ICT. This paper analyses the implications that multimedia assisted instructional package have in enhancing the achievement of Class IX students in learning. The paper envisages that the application of ICT in pedagogy can enhance the interest of students in English Learning

An overview of technology transfer in industry

The objective of this review article is to study how technology is transferred in the pharmaceutical industry. This review article is to discuss the procedure for technology transfer process in pharmaceutical industry, importance of technology transfer, reasons for using technology transfer, methods of technology transfer, facets of technology transfer, list of institutes in Indian assisting in technology transfer, organization of technology transfer, function of technology transfer, steps involved in technology transfer, few case of involved in the technology transfer in the pharmaceutical industry and understand the aspects related with technology transfer

The influence of enclosure design on diurnal activity and stereotypic behaviour in captive Malayan Sun bears (Helarctos malayanus)

The effect of enclosure design on diurnal activity and stereotypic behaviour was assessed in 17 adult Malayan Sun bears (Helarctos malayanus), kept either in barren indoor enclosures or relatively enriched outdoor enclosures. Locomotion was the most frequent activity observed in the indoor bears, followed by resting. In contrast, conspecifics housed outdoors spent most of the time resting. Eleven forms of stereotypic behaviours were recorded in the bears, with pacing being the most common. The frequency and repertoire of stereotypies were significantly higher in the indoor bears irrespective of enclosure size. Novel forms of locomotor (forward-reverse pacing) and oral (allo-sucking) stereotypies were recorded. Oral stereotypies were predominant in the bears housed indoors, while patrolling was confined to the outdoor bears. Enclosure complexity significantly influences activity budget and occurrence of stereotypic behaviours, highlighting the importance of appropriate enclosure design and enrichment for the welfare of captive bears

An unusual case of idiopathic inflammatory myopathy presenting with organizing pneumonia as cavitary lesions

A young woman presented with gradually progressive breathlessness, cough and muscle weakness for one and a half year. Her chest radiograph showed multiple, bilateral thin-walled cavitary lesions. Her serum was found to be positive for anti-Jo1 antibodies on serology. Histopathology of lung lesions was suggestive of organizing pneumonia. The muscle biopsy demonstrated a myopathic pattern. On the basis of these findings she was diagnosed to be the case of idiopathic inflammatory myopathy. Her condition improved significantly after treatment with steroids

Analysis of mechanism of sand deposition inside a fishing port using BG model

A large amount of sand deposited in the wave-shelter zone of Ohtsu fishing port located in northern Ibaraki Prefecture, Japan, resulting in a difficulty in navigation at the pot entrance. The BG model (a three-dimensional model for predicting beach changes based on Bagnold's concept) ws used to solve this problem. Measures against sand deposition inside the port were investigated and the most appropriate measure found for preventing sand deposition was the extension of a jetty by 100 m at the tip of the west breakwater. The applicability of the BG model to such prediction was confirmed

Pediatric duodenal cancer and biallelic mismatch repair gene mutations

Gastrointestinal malignancies are extremely rare in the pediatric population, and duodenal cancers represent an even more unusual entity. Intestinal cancers in young adults and children have been observed to be associated with functional deficiencies of the mismatch repair (MMR) system causing a cancer-predisposition syndrome. We report the case of a 16-year-old female with duodenal adenocarcinoma and past history of medulloblastoma found to have a novel germline bialleleic truncating mutation (c.[949C>T]+[949C>T]) of the PMS2 gene. Pediatr Blood Cancer 2009;53:116–120. © 2009 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62997/1/21957_ftp.pd